The game is dominated by talk of the return of former Barcelona and Manchester City manager Pep Guardiola at the Nou Camp but other European top sides will be in action also.
The Blaugrana lead Group C with six points having scored nine times in their opening two fixtures against Celtic and Borussia Monchengladbach respectively while City are below on four points with seven goals.
Guardiola‘s side is winless in its last three matches across all competitions and are currently on a poor run of form.
Barcelona will welcome back star player Lionel Messi in the team having played against Deportivo in La Liga on 15th October, 2016.
In the other Group C game, Celtic who put up a spirited performance against Manchester City host Borussia Monchengladbach looking for maximum points to boost their qualification chances.
The Gunners are favourites in the game and a win will boost their passage to the knock-out phase.
In the other games, last season’s finalist Atletico Madrid travel to Russia to take on FC Rostov.
Bayern Munich who host PSV Eindhoven at the Allianz Allena began the season with eight straight wins in all competitions but are now without a win in three games and suffered their first defeat of the season at Atletico Madrid in their last European match.
ALL UCL FIXTURES
Barcelona vs. Manchester City
Napoli vs. Bestikas
Arsenal vs. Ludogorets
FC Rostov vs. Atletico Madrid
Dynamo Kyiv vs. Benfica
Paris Saint-Germain vs. FC Basel
Celtic vs. Borussia Monchengladbach
Bayern Munich vs. PSV Eindhoven