De Bruyne has been out for the last two months due the right knee injury he had sustained earlier in August.
Manchester United loanee Timothy Fosu-Mensah fell on De Bryune’s knee that escalated the injury.
The Belgian will miss Manchester weekend match against Southampton. He may also fight hard to come back to face Chelsea on December 8.
‘The previous injury was more dangerous than this one,’ Guardiola said. ‘The doctor said he was sad. Today he was less sad and the next day he’ll be strong again.
‘I’m more concerned when it’s muscular injuries. When it’s a trauma he’s unlucky with that situation. We are a stronger team with Kevin than without him but we have to live with that.’
De Bruyne will have a trip to Barcelona for treatment alongside with Dr Ramon Cugat.
‘He’ll spend the time with his new boy and his family,’ Guardiola added. ‘Hopefully after the international break, there’ll be two or three more games and after that he’ll back.
‘That will help us in the last part that he will be fresh in mind and body and help us reach our targets. Fortunately it is no surgery.